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期刊论文 22

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网络设计问题；代理模型优化；交通规划；启发式算法 1

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An assessment of surrogate fuel using Bayesian multiple kernel learning model in sight of sooting tendency

《能源前沿（英文）》 2022年 第16卷 第2期   页码 277-291 doi: 10.1007/s11708-021-0731-6

摘要： An integrated and systematic database of sooting tendency with more than 190 kinds of fuels was obtained through a series of experimental investigations. The laser-induced incandescence (LII) method was used to acquire the 2D distribution of soot volume fraction, and an apparatus-independent yield sooting index (YSI) was experimentally obtained. Based on the database, a novel predicting model of YSI values for surrogate fuels was proposed with the application of a machine learning method, named the Bayesian multiple kernel learning (BMKL) model. A high correlation coefficient (0.986) between measured YSIs and predicted values with the BMKL model was obtained, indicating that the BMKL model had a reliable and accurate predictive capacity for YSI values of surrogate fuels. The BMKL model provides an accurate and low-cost approach to assess surrogate performances of diesel, jet fuel, and biodiesel in terms of sooting tendency. Particularly, this model is one of the first attempts to predict the sooting tendencies of surrogate fuels that concurrently contain hydrocarbon and oxygenated components and shows a satisfying matching level. During surrogate formulation, the BMKL model can be used to shrink the surrogate candidate list in terms of sooting tendency and ensure the optimal surrogate has a satisfying matching level of soot behaviors. Due to the high accuracy and resolution of YSI prediction, the BMKL model is also capable of providing distinguishing information of sooting tendency for surrogate design.

关键词： sooting tendency     yield sooting index     Bayesian multiple kernel learning     surrogate assessment     surrogate formulation    

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Method for solving the nonlinear inverse problem in gas face seal diagnosis based on surrogate models

《机械工程前沿（英文）》 2022年 第17卷 第3期 doi: 10.1007/s11465-022-0689-z

摘要： Physical models carry quantitative and explainable expert knowledge. However, they have not been introduced into gas face seal diagnosis tasks because of the unacceptable computational cost of inferring the input fault parameters for the observed output or solving the inverse problem of the physical model. The presented work develops a surrogate-model-assisted method for solving the nonlinear inverse problem in limited physical model evaluations. The method prepares a small initial database on sites generated with a Latin hypercube design and then performs an iterative routine that benefits from the rapidity of the surrogate models and the reliability of the physical model. The method is validated on simulated and experimental cases. Results demonstrate that the method can effectively identify the parameters that induce the abnormal signal output with limited physical model evaluations. The presented work provides a quantitative, explainable, and feasible approach for identifying the cause of gas face seal contact. It is also applicable to mechanical devices that face similar difficulties.

关键词： surrogate model     gas face seal     fault diagnosis     nonlinear dynamics     tribology    

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Reliability-based design optimization of offshore wind turbine support structures using RBF surrogate

《结构与土木工程前沿（英文）》   页码 1086-1099 doi: 10.1007/s11709-023-0976-8

摘要： Reliability-based design optimization of offshore wind turbine support structures using RBF surrogate model

关键词： RBF     surrogate model     turbine support structures    

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double-layer barrel vaults using genetic and pattern search algorithms and optimized neural network as surrogate

《结构与土木工程前沿（英文）》 2023年 第17卷 第3期   页码 378-395 doi: 10.1007/s11709-022-0899-9

摘要： This paper presents a combined method based on optimized neural networks and optimization algorithms to solve structural optimization problems. The main idea is to utilize an optimized artificial neural network (OANN) as a surrogate model to reduce the number of computations for structural analysis. First, the OANN is trained appropriately. Subsequently, the main optimization problem is solved using the OANN and a population-based algorithm. The algorithms considered in this step are the arithmetic optimization algorithm (AOA) and genetic algorithm (GA). Finally, the abovementioned problem is solved using the optimal point obtained from the previous step and the pattern search (PS) algorithm. To evaluate the performance of the proposed method, two numerical examples are considered. In the first example, the performance of two algorithms, OANN + AOA + PS and OANN + GA + PS, is investigated. Using the GA reduces the elapsed time by approximately 50% compared with using the AOA. Results show that both the OANN + GA + PS and OANN + AOA + PS algorithms perform well in solving structural optimization problems and achieve the same optimal design. However, the OANN + GA + PS algorithm requires significantly fewer function evaluations to achieve the same accuracy as the OANN + AOA + PS algorithm.

关键词： optimization     surrogate models     artificial neural network     SAP2000     genetic algorithm    

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Nanocrystal technology for drug formulation and delivery

Tzu-Lan CHANG, Honglei ZHAN, Danni LIANG, Jun F. LIANG

《化学科学与工程前沿（英文）》 2015年 第9卷 第1期   页码 1-14 doi: 10.1007/s11705-015-1509-3

摘要： With the development of modern technology like high throughput screening, combinatorial chemistry and computer aid drug design, the drug discovery process has been dramatically accelerated. However, new drug candidates often exhibit poor aqueous or even organic medium solubility. Additionally, many of them may have low dissolution velocity and low oral bioavailability. Nanocrystal formulation sheds new light on advanced drug development. Due to small (nano- or micro- meters) sizes, the increased surface-volume ratio leads to dramatically enhanced drug dissolution velocity and saturation solubility. The simplicity in preparation and the potential for various administration routes allow drug nanocrystals to be a novel drug delivery system for specific diseases (i.e. cancer). In addition to the comprehensive review of different technologies and methods in drug nanocrystal preparation, suspension, and stabilization, we will also compare nano- and micro-sized drug crystals in pharmaceutical applications and discuss current nanocrystal drugs on the market and their limitations.

关键词： drug nanocrystal     nanotechnology     formulation     bioavailability     stabilizers     drug delivery    

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Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

《化学科学与工程前沿（英文）》 2014年 第8卷 第2期   页码 225-232 doi: 10.1007/s11705-014-1429-7

摘要： Semi-solid materials represent an important category of inactive ingredients (excipients) of pharmaceutical products. Here we review several common semi-solid polymers currently used in the controlled release formulations of many drugs. These polymers are selected based on their importance and broad scope of application in FDA-approved drug products and include several polysaccharides (cellulose, starch, chitosan, alginate) and carbomers, a group of mucoadhesive synthetic polymers. Glyceride-based polymers used in self-emulsifying drug delivery systems (SEDDS) will also be discussed for its importance in formulating poorly water-soluble drugs. Unique features and advantages of each type of semi-solid materials are discussed and examples of their use in oral delivery of drugs are provided. Finally, future prospects of developing new and better semi-solid excipients are discussed with the objective of facilitating clinical translation.

关键词： controlled release     drug delivery     semi-solids     polymer     excipient    

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Implementation of total Lagrangian formulation for the elasto-plastic analysis of plane steel frames

Bing XIA, Yuching WU, Zhanfei HUANG

《结构与土木工程前沿（英文）》 2012年 第6卷 第3期   页码 257-266 doi: 10.1007/s11709-012-0163-9

摘要： In this paper, the co-rotational total Lagrangian forms of finite element formulations are derived to perform elasto-plastic analysis for plane steel frames that either experience increasing external loading at ambient temperature or constant external loading at elevated temperatures. Geometric nonlinearities and thermal-expansion effects are considered. A series of programs were developed based on these formulations. To verify the accuracy and efficiency of the nonlinear finite element programs, numerical benchmark tests were performed, and the results from these tests are in a good agreement with the literature. The effects of the nonlinear terms of the stiffness matrices on the computational results were investigated in detail. It was also demonstrated that the influence of geometric nonlinearities on the incremental steps of the finite element analysis for plane steel frames in the presence of fire is limited.

关键词： co-rotational     total Lagrangian     geometrical nonlinearity     fire     elasto-plastic    

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approach for structural damage detection using meta-heuristic algorithms and group method of data handling surrogate

Hamed FATHNEJAT, Behrouz AHMADI-NEDUSHAN

《结构与土木工程前沿（英文）》 2020年 第14卷 第4期   页码 907-929 doi: 10.1007/s11709-020-0628-1

摘要： In this study, the performance of an efficient two-stage methodology which is applied in a damage detection system using a surrogate model of the structure has been investigated. In the first stage, in order to locate the damage accurately, the performance of the modal strain energy based index for using different numbers of natural mode shapes has been evaluated using the confusion matrix. In the second stage, to estimate the damage extent, the sensitivity of most used modal properties due to damage, such as natural frequency and flexibility matrix is compared with the mean normalized modal strain energy (MNMSE) of suspected damaged elements. Moreover, a modal property change vector is evaluated using the group method of data handling (GMDH) network as a surrogate model during damage extent estimation by optimization algorithm; in this part of methodology, the performance of the three popular optimization algorithms including particle swarm optimization (PSO), bat algorithm (BA), and colliding bodies optimization (CBO) is examined and in this regard, root mean square deviation ( ) based on the modal property change vector has been proposed as an objective function. Furthermore, the effect of noise in the measurement of structural responses by the sensors has also been studied. Finally, in order to achieve the most generalized neural network as a surrogate model, GMDH performance is compared with a properly trained cascade feed-forward neural network (CFNN) with log-sigmoid hidden layer transfer function. The results indicate that the accuracy of damage extent estimation is acceptable in the case of integration of PSO and MNMSE. Moreover, the GMDH model is also more efficient and mimics the behavior of the structure slightly better than CFNN model.

关键词： two-stage method     modal strain energy     surrogate model     GMDH     optimization damage detection    

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Synergistic optimization framework for the process synthesis and design of biorefineries

《化学科学与工程前沿（英文）》 2022年 第16卷 第2期   页码 251-273 doi: 10.1007/s11705-021-2071-9

摘要： The conceptual process design of novel bioprocesses in biorefinery setups is an important task, which remains yet challenging due to several limitations. We propose a novel framework incorporating superstructure optimization and simulation-based optimization synergistically. In this context, several approaches for superstructure optimization based on different surrogate models can be deployed. By means of a case study, the framework is introduced and validated, and the different superstructure optimization approaches are benchmarked. The results indicate that even though surrogate-based optimization approaches alleviate the underlying computational issues, there remains a potential issue regarding their validation. The development of appropriate surrogate models, comprising the selection of surrogate type, sampling type, and size for training and cross-validation sets, are essential factors. Regarding this aspect, satisfactory validation metrics do not ensure a successful outcome from its embedded use in an optimization problem. Furthermore, the framework’s synergistic effects by sequentially performing superstructure optimization to determine candidate process topologies and simulation-based optimization to consolidate the process design under uncertainty offer an alternative and promising approach. These findings invite for a critical assessment of surrogate-based optimization approaches and point out the necessity of benchmarking to ensure consistency and quality of optimized solutions.

关键词： biotechnology     surrogate modelling     superstructure optimization     simulation-based optimization     process design    

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网络设计问题的一种代理模型优化算法 Article

Meng LI, Xi LIN, Xi-qun CHEN

《信息与电子工程前沿（英文）》 2017年 第18卷 第11期   页码 1693-1704 doi: 10.1631/FITEE.1601403

摘要： 由于其双层规划结构本质上的非凸性，交通网络设计问题一直以来都是交通规划领域中最为困难的问题之一。尤其在考虑混合了连续变量与离散变量的决策变量时，得到的混合网络设计形式进一步增加了问题的难度。本文引入了一种代理模型优化算法，用以解决三种不同种类的网络设计问题，包括连续、离散与混合的情形。我们证明了提出的算法在解决连续网络设计问题时，能够确保“渐进完全收敛”的性质，即在给定足够长的计算时间时，算法能够以概率1收敛到全局最优解。为了展示本文提出的框架在实际问题中的表现，我们用大量的算例对比了代理模型算法与大量用于解决网络设计问题的经典算法、启发式算法的效果。结果表明，以效率与精确度而论，代理模型算法是其中最优秀之一，同时它还能够有效地解决超过20个变量的较大规模的问题。本文提出的代理模型优化框架也能够用于解决交通领域的其他优化问题。

关键词： 网络设计问题；代理模型优化；交通规划；启发式算法    

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A novel finite element formulation for static bending analysis of functionally graded porous sandwich

Van Chinh NGUYEN; Trung Thanh TRAN; Trung NGUYEN-THOI; Quoc-Hoa PHAM

《结构与土木工程前沿（英文）》 2022年 第16卷 第12期   页码 1599-1620 doi: 10.1007/s11709-022-0891-4

摘要： This article aims to propose a finite element formulation based on Quasi-3D theory for the static bending analysis of functionally graded porous (FGP) sandwich plates. The FGP sandwich plates consist of three layers including the bottom skin of homogeneous metal, the top skin of fully ceramic and the FGP core layer with uneven porosity distribution. A quadrilateral (Q4) element with nine degrees of freedom (DOFs) per node is derived and employed in analyzing the static bending response of the plate under uniform and/or sinusoidally distributed loads. The accuracy of the present finite element formulation is verified by comparing the obtained numerical results with the published results in the literature. Then, some numerical examples are performed to examine the effects of the parameters including power-law index k and porosity coefficient ξ on the static bending response of rectangular FGP sandwich plates. In addition, a problem with a complicated L-shape model is conducted to illustrate the superiority of the proposed finite element method.

关键词： sandwich plates     functionally graded porous     static bending     Quasi-3D theory     Q4 element    

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Robust isogeometric topology optimization for piezoelectric actuators with uniform manufacturability

《机械工程前沿（英文）》 2022年 第17卷 第2期 doi: 10.1007/s11465-022-0683-5

摘要： Piezoelectric actuators have received substantial attention among the industry and academia due to quick responses, such as high output force, high stiffness, high accuracy, and precision. However, the design of piezoelectric actuators always suffers from the emergence of several localized hinges with only one-node connection, which have difficulty satisfying manufacturing and machining requirements (from the over- or under-etching devices). The main purpose of the current paper is to propose a robust isogeometric topology optimization (RITO) method for the design of piezoelectric actuators, which can effectively remove the critical issue induced by one-node connected hinges and simultaneously maintain uniform manufacturability in the optimized topologies. In RITO, the isogeometric analysis replacing the conventional finite element method is applied to compute the unknown electro elastic fields in piezoelectric materials, which can improve numerical accuracy and then enhance iterative stability. The erode–dilate operator is introduced in topology representation to construct the eroded, intermediate, and dilated density distribution functions by non-uniform rational B-splines. Finally, the RITO formulation for the design of piezoelectric materials is developed, and several numerical examples are performed to test the effectiveness and efficiency of the proposed RITO method.

关键词： piezoelectric actuator     isogeometric topology optimization     uniform manufacturability     robust formulation     density distribution function    

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Controlling interstory drift ratio profiles via topology optimization strategies

《结构与土木工程前沿（英文）》 2023年 第17卷 第2期   页码 165-178 doi: 10.1007/s11709-022-0892-3

摘要： An approach to control the profiles of interstory drift ratios along the height of building structures via topology optimization is proposed herein. The theoretical foundation of the proposed approach involves solving a min–max optimization problem to suppress the maximum interstory drift ratio among all stories. Two formulations are suggested: one inherits the bound formulation and the other utilizes a p-norm function to aggregate all individual interstory drift ratios. The proposed methodology can shape the interstory drift ratio profiles into inverted triangular or quadratic patterns because it realizes profile control using a group of shape weight coefficients. The proposed formulations are validated via a series of numerical examples. The disparity between the two formulations is clear. The optimization results show the optimal structural features for controlling the interstory drift ratios under different requirements.

关键词： interstory drift ratio     aggregation function     bound formulation     min–max problem     topology optimization    

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ISO 18186国际标准的制定及思考

包起帆

《中国工程科学》 2012年 第14卷 第10期   页码 23-26

摘要：

随着我国经济的快速发展和技术水平的不断提高，如何提升我国在国际标准化活动中的影响力和话语权的呼声越来越高。国际标准《ISO 18186∶2011 集装箱-RFID货运标签系统》于2011年由国际标准化组织(ISO)正式发布，成为自我国开始参与国际标准化组织活动以来，在物流、物联网领域首个由中国发起、起草和主导的国际标准。这项国际标准是以“构建包括系统平台建设、软硬件设计、商业化运行模式和系统应用的完整产业链”为技术支撑，沿着“技术专利化、专利标准化、标准国际化”的路线，先形成国家标准GB/T 23678—2009，并同步推进相关国际标准的制定。这里将对国际标准制定的过程和方法进行介绍，分享一些经验，以期为我国创新成果上升，为国际标准提供一些有益帮助。

关键词： 国际标准制定     集装箱RFID（无线射频识别）     ISO 18186    

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Controlled drug delivery systems: the next 30 years

Yeonhee YUN,Byung Kook LEE,Kinam PARK

《化学科学与工程前沿（英文）》 2014年 第8卷 第3期   页码 276-279 doi: 10.1007/s11705-014-1426-x

摘要： The drug delivery scientists need to reexamine the advances made during the past 60 years, analyze our current abilities, and design the future technologies that will propel us to achieve the next level of drug delivery technologies. History shows that the first generation (1G) of drug delivery research during 1950–1980 was quite productive, while the second generation (2G) technologies developed during 1980–2010 were not as prolific. The ultimate goal of drug delivery research is to develop clinically useful formulations to treat various diseases. Effective drug delivery systems can be developed by overcoming formulation barriers and/or biological barriers. The engineering approach has a limit in solving the problem, if biological difficulties are not clearly identified and understood. The third generation (3G) drug delivery systems will have to focus on understanding the biological barriers so that they can be overcome by engineering manipulation of the drug delivery systems. Advances in the next 30 years will be most accelerated by starting open dialogues without any preconceived ideas on drug delivery technologies. The new generation of drug delivery scientists needs to be aware of the successes and limitations of the existing technologies to design the new technologies for meaningful advances in the future.

关键词： drug delivery     history     formulation barriers     nanotechnology     clinical product    

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标题 作者 时间 类型 操作

An assessment of surrogate fuel using Bayesian multiple kernel learning model in sight of sooting tendency

期刊论文

Method for solving the nonlinear inverse problem in gas face seal diagnosis based on surrogate models

期刊论文

Reliability-based design optimization of offshore wind turbine support structures using RBF surrogate

期刊论文

double-layer barrel vaults using genetic and pattern search algorithms and optimized neural network as surrogate

期刊论文

Nanocrystal technology for drug formulation and delivery

Tzu-Lan CHANG, Honglei ZHAN, Danni LIANG, Jun F. LIANG

期刊论文

Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

期刊论文

Implementation of total Lagrangian formulation for the elasto-plastic analysis of plane steel frames

Bing XIA, Yuching WU, Zhanfei HUANG

期刊论文

approach for structural damage detection using meta-heuristic algorithms and group method of data handling surrogate

Hamed FATHNEJAT, Behrouz AHMADI-NEDUSHAN

期刊论文

Synergistic optimization framework for the process synthesis and design of biorefineries

期刊论文

网络设计问题的一种代理模型优化算法

Meng LI, Xi LIN, Xi-qun CHEN

期刊论文

A novel finite element formulation for static bending analysis of functionally graded porous sandwich

Van Chinh NGUYEN; Trung Thanh TRAN; Trung NGUYEN-THOI; Quoc-Hoa PHAM

期刊论文

Robust isogeometric topology optimization for piezoelectric actuators with uniform manufacturability

期刊论文

Controlling interstory drift ratio profiles via topology optimization strategies

期刊论文

ISO 18186国际标准的制定及思考

包起帆

期刊论文

Controlled drug delivery systems: the next 30 years

Yeonhee YUN,Byung Kook LEE,Kinam PARK

期刊论文